imtoken苹果版钱包|ebox是什么意思
作者： imtoken苹果版钱包
2024-03-10 20:55:16
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eBox开发板：简化STM32编程的物联网开发板-打造工程师的专属团购平台-电子发烧友网
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eBox-SPARK开发板是一款可直接编程的STM32开发板，让STM32的编程开发变得同Arduino编程一样简单。是什么利器能让STM32编程如此简单呢？答案就是eBox-SPARK开发板上所运行的系统eBox！eBox是什么eBox是一个运行在STM32平台上的软硬件一体化的解决方案和开发平台，涵盖了STM32外设层、芯片驱动层、系统层、标准应用软件层、用户软件层和bootloader。eBox寓意简单的盒子，彻底简化STM32编程！把“拿来主义”贯彻到底！我与eBox的故事自己在经历过这些各种项目，很多都是用STM32系列单片机作为主控来实现的，虽然代码写了很多，但是总觉得每次做项目都要花很长时间调试驱动，即使网上有网友写的驱动可以下载，但是肯定要改很多地方才能使用，经常没那么顺利，导致在调试的过程中要不断的在检查硬件和检查软件的死循环中。难道是我能力有限，还是方法不对？在想了很久之后，萌生了一个想法，就是让单片机的开发驱动规范化，简单化，让用户像装Windows驱动一样，下载安装即可。这样我在保证我硬件连接没有问题的情况下，驱动就可以很快的调试通过，可以节约我大量的时间来处理应用层的逻辑事物。eBox就应运而生了。当然经过不断的改进ebox不仅仅提供了标准的驱动层，还有跟多标准的服务组件，可以满足用户的快速开发。我对STM32编程的思考脱胎换骨，再度归来第一次众筹结束后，eBox增加了众多粉丝，他们也加入到了开发行列中，为eBox增添了很多功能。包括驱动库、标准软件等等。为了更方便用户的测试使用，我又开发了一个拓展版，可以让用户一个板子在手，就可以做所有的外设实验，这就是IOT拓展版。他支持了WIFI 、EEPROM、FLASH、CAN、485、LCD、RGB彩灯、温湿度、红外接收头、红外发射管等等功能，配套的软件也已经做好了。用户可以真正体验eBox编程带来的乐趣和极致的体验！我们在做的绝不是一个简单的开发板！而是为所有工程师搭建一个完美的软件和硬件开发平台，成为工程师最好的助手，成为新手入门STM32最快的捷径！敢于抛弃传统，才能走向未来！eBox开发平台适合哪些人？电子、计算机相关专业开始学习STM32的同学从事STM32开发的工程人员想实现STM32快速项目开发的工程人员所有支持国产嵌入式操作系统发展的志同道合的同志支持eBox开发平台可以获得什么？一套eBox开发板（包括STM32核心板、拓展版<带显示屏和wifi功能>、下载调试器）eBox开发教程，电路图eBox现有的开源驱动、标准应用、操作系统代码eBox软件生态系统中所有开发者共享的开源代码快速进行STM32编程开发的方法良好的编程习惯和代码框架设计eBox固件库优势eBox固件库使用c++的方式封装了STM32的固件库，给用户呈现一个非常简单的应用接口。让用户无需再去详细阅读芯片手册，也无需详细了解官方复杂的固件库函数。只要知道eBox的API即可完成你想要的功能。让STM32也能像Arduino一样方便的编程。▲完美标准程序框架 ▲全面的外设支持，人性化API接口，简化编程。重新定位API接口，抛弃传统的思路，站在用户的角度去设计接口，比如PWM以频率和占空比参数初始化；定时器以中断频率为参数初始化；串口以波特率为参数进行初始化；SPI以MODE0/1/2/3、速度、数据大小端为参数初始化I2C以速度为参数初始化，这样一来用户使用起来就非常简单。外设固件库列表●数字IO，PA0-PG15所有引脚●支持任意8位IO分组，方便总线类型器件编程●ADC1的16个通道，CH1-16●通用定时器TIM2、3、4、5、6、7的定时中断●高级定时器TIM1的定时中断●12路PWM●12路输入捕获通道●16通道的外部中断，可影射所有引脚●硬件SPI1、2、3●硬件I2C1、2●软件SPI，支持任意IO配置●软件件I2C，支持任意IO配置●串口，支持USART1、2、3、4、5●实时时钟RTC●内部flash编程●独立看门狗●CAN控制器●USB控制器 ▲开源共享驱动，解决移植大问题用户可以通过eBox官方渠道获取免费已有开源驱动程序，基于eBox的标准驱动加载到本地工程后，文件不需要任何修改、用户只需在应用层创建芯片对象的时候重新填写自己的硬件接口就可以使用。驱动就像一个黑盒子，用户不用关心如何实现，只需调用其公共接口即可。增加了驱动代码的复用率，大大降低了驱动移所占用的时间。驱动库（新增部分）：●1.8寸LCD显示器驱动●W25X16系列spi flash存储芯片驱动●AT24C02存储芯片驱动●WIFI驱动●485总线●can总线●红外发射●红外接收●DHT11温湿度●更多驱动程序不再一一列举 ▲标准应用库的建立标准应用程序就是解决通用或者特定领域内的一些标准程序，统一其编程规范和接口，争取以后可以做到让用户一看函数名称就能知道怎么使用。应用层（部分新增）●网络应用程序●文件系统FATFS●modbus●WIFI网络应用层●高级日历程序●色彩转换控制器●增加了很多系统功能函数和用户常用函数▲操作系统eBox目前支持三个操作系统ucos、freertos这两个系统在嵌入式领域占有绝对重量的地位。ebox_os是自主开发的一个小型操作系统，包含了任务调度、挂起、唤醒等简单的功能，操作系统完全开源，也是用户学习操作系统原理的典型例子。●支持eBox_OS●支持UCOS●支持FreertOS中国梦——EBOX软件生态系统的建立目前已经有很多用户开始使用eBox固件库进行开发，他们也在不断的共享驱动库、应用程序，其中包括CAN驱动、modbus驱动、OLED驱动、USB驱动、SD卡bug修正、WiFi驱动等等，在不久的以后会有更多用户贡献更多的代码，让大家体验到软件生态系统的真正强大之处。整个生态系统的发展需要大家共同的努力。大家不断的共享出更优秀的代码eBox才能发展的更快。至此，我要感谢大家的无私奉献，感谢你们为国人固件库的发展支持，能真正的参与eBox生态系统的发展。
常见问题
本次的版本和第一次众筹的版本有哪些改变？
硬件上对主板进行了重新布局并增加传感器，同时新增扩展版带显示屏和WiFi功能。软件上完善驱动库。
09日
06月
【eBox二期众筹结束】公开资料、发货通知、抽奖记录
eBox二期众筹已经结束了。首先要感谢大家对ebox的支持！也感谢电子发烧友平台给我的大力支持。这一期的效果明显没有达到预期目标，主要原因在于我这段时间比较忙，没办法经常跟大家沟通交流，发帖跟进。但是为了不让大家失望，我还是决定给大家发货。
09日
05月
eBox开发板教程：教你如何开挂一般上手编程STM32（连载二）
讲解eBox核心固件库的所有芯片级外设的封装接口和使用方法。包含了GPIO、UART、EXIT、ADC、TIMER、INCAPTURE、FLASH、IDWG、RTC、SYS、CAN等基础外设。
05日
05月
eBox开发板教程：教你如何开挂一般上手编程STM32(连载一)
主要介绍eBox固件库及教程与指南的配合使用，并对eBox三个组件的功能及板卡细节介绍，以电路形式讲解eBox三个组件中各个模块作用及如何实现功能
常见问题
1、本次的版本和第一次众筹的版本有哪些改变？
硬件上对主板进行了重新布局并增加传感器，同时新增扩展版带显示屏和WiFi功能。软件上完善驱动库。
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282834323
2016-05-13
下载积分不足，嘻嘻
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hitzhxy
2016-05-06
这个进度有点慢啊！这个是不是已经开发完了？众筹不成功应该可以直接购买吧？
hitzhxy:淘宝是一代的吧(2016-05-10)
A670521546:这个是最新的一代(2016-05-09)
李牧林:淘宝有(2016-05-08)
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1Discovery
2Binding
3Role in the circadian clock
4Role of proteins which bind to E-boxes
Toggle Role of proteins which bind to E-boxes subsection
4.1CLOCK-ARNTL complex
4.2MYC (c-Myc, an oncogene)
4.3MYOD1 (MyoD)
4.4MyoG (Myogenin)
4.5TCF3 (E47)
5Recent research
6References
7External links
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From Wikipedia, the free encyclopedia
DNA response element in some eukaryotes
An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.[1] Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG,[2] is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA.
Discovery[edit]
The E-box was discovered in a collaboration between Susumu Tonegawa's and Walter Gilbert's laboratories in 1985 as a control element in immunoglobulin heavy-chain enhancer.[3][4] They found that a region of 140 base pairs in the tissue-specific transcriptional enhancer element was sufficient for different levels of transcription enhancement in different tissues and sequences. They suggested that proteins made by specific tissues acted on these enhancers to activate sets of genes during cell differentiation.
In 1989, David Baltimore's lab discovered the first two E-box binding proteins, E12 and E47.[5] These immunoglobulin enhancers could bind as heterodimers to proteins through bHLH domains. In 1990, another E-protein, ITF-2A (later renamed E2-2Alt) was discovered that can bind to immunoglobulin light chain enhancers.[6] Two years later, the third E-box binding protein, HEB, was discovered by screening a cDNA library from HeLa cells.[7] A splice-variant of the E2-2 was discovered in 1997 and was found to inhibit the promoter of a muscle-specific gene.[8]
Since then, researchers have established that the E-box affects gene transcription in several eukaryotes and found E-box binding factors that identify E-box consensus sequences.[9] In particular, several experiments have shown that the E-box is an integral part of the transcription-translation feedback loop that comprises the circadian clock.
Binding[edit]
E-box binding proteins play a major role in regulating transcriptional activity. These proteins usually contain the basic helix-loop-helix protein structural motif, which allows them to bind as dimers.[10] This motif consists of two amphipathic α-helices, separated by a small sequence of amino acids, that form one or more β-turns. The hydrophobic interactions between these α-helices stabilize dimerization. Besides, each bHLH monomer has a basic region, which helps mediate recognition between the bHLH monomer and the E-box (the basic region interacts with the major groove of the DNA). Depending on the DNA motif ("CAGCTG" versus "CACGTG") the bHLH protein has a different set of basic residues.
Relative Position of CTRR and E-Box
The E-box binding is modulated by Zn2+ in mice. The CT-Rich Regions (CTRR) located about 23 nucleotides upstream of the E-box is important in E-box binding, transactivation (increased rate of genetic expression), and transcription of circadian genes BMAL1/NPAS2 and BMAL1/CLOCK complexes.[11]
The binding specificity of different E-boxes is found to be essential in their function. E-boxes with different functions have a different number and type of binding factor.[12]
The consensus sequence of the E-box is usually CANNTG; however, there exist other E-boxes of similar sequences called noncanonical E-boxes. These include, but are not limited to:
CACGTT sequence 20 bp upstream of the mouse Period2 (PER2) gene and regulates its expression[13]
CAGCTT sequence found within the MyoD core enhancer[14]
CACCTCGTGAC sequence in the proximal promoter region of human and rat APOE, which is a protein component of lipoproteins.[15]
Role in the circadian clock[edit]
The link between E-box-regulated genes and the circadian clock was discovered in 1997, when Hao, Allen, and Hardin (Department of Biology at Texas A&M University) analyzed rhythmicity in the period (per) gene in Drosophila melanogaster.[16] They found a circadian transcriptional enhancer upstream of the per gene within a 69 bp DNA fragment. Depending upon PER protein levels, the enhancer drove high levels of mRNA transcription in both LD (light-dark) and DD (constant darkness) conditions. The enhancer was found to be necessary for high-level gene expression but not for circadian rhythmicity. It also works independently as a target of the BMAL1/CLOCK complex.
The E-box plays an important role in circadian genes; so far, nine E/E'BOX controlled circadian genes have been identified: PER1, PER2, BHLHB2, BHLHB3, CRY1, DBP, Nr1d1, Nr1d2, and RORC.[17] As the E-box is connected to several circadian genes, it is possible that the genes and proteins associated with it are "crucial and vulnerable points in the (circadian) system."[18]
The E-box is one of the top five transcription factor families associated with the circadian phase and is found in most tissues.[19] A total of 320 E-box-controlled genes are found in the SCN (suprachiasmatic nucleus), liver, aorta, adrenal, WAT (white adipose tissue), brain, atria, ventricle, prefrontal cortex, skeletal muscle, BAT (brown adipose tissue), and calvarial bone.
E-box like CLOCK-related elements (EL-box; GGCACGAGGC) are also important in maintaining circadian rhythmicity in clock-controlled genes. Similarly to the E-box, the E-box like CLOCK related element can also induce transcription of BMAL1/CLOCK, which can then lead to expression in other EL-box containing genes (Ank, DBP, Nr1d1).[20] However, there are differences between the EL-box and the regular E-box. Suppressing DEC1 and DEC2 has a stronger effect on E-box than on EL-box. Furthermore, HES1, which can bind to a different consensus sequence (CACNAG, known as the N-box), shows suppression effect in EL-box, but not in E-box.
Both non-canonical E-boxes and E-box-like sequences are crucial for circadian oscillation. Recent research on this forms an hypothesis that either a canonical or non-canonical E-box followed by an E-box like sequence with 6 base pair interval in between is a necessary combination for circadian transcription.[21] In silico analysis also suggests that such an interval existed in other known clock-controlled genes.
Role of proteins which bind to E-boxes[edit]
There are several proteins that bind to the E-box and affect gene transcription.
CLOCK-ARNTL complex[edit]
The CLOCK-ARNTL (BMAL1) complex is an integral part of the mammalian circadian cycle and vital in maintaining circadian rhythmicity.
Knowing that binding activates transcription of the per gene in the promoter region, researchers discovered in 2002 that DEC1 and DEC2 (bHLH transcription factors) repressed the CLOCK-BMAL1 complex through direct interaction with BMAL1 and/or competition for E-box elements. They concluded that DEC1 and DEC2 were regulators of the mammalian molecular clock.[22]
In 2006, Ripperger and Schibler discovered that the binding of this complex to the E-box drove circadian DBP transcription and chromatin transitions (a change from chromatin to facultative heterochromatin).[23] It was concluded that CLOCK regulates DBP expression by binding to E-box motifs in enhancer regions located in the first and second introns.
MYC (c-Myc, an oncogene)[edit]
MYC (c-Myc), a gene that codes for a transcription factor Myc, is important in regulating mammalian cell proliferation and apoptosis.
In 1991, researchers tested whether c-Myc could bind to DNA by dimerizing it to E12. Dimers of E6, the chimeric protein, were able to bind to an E-box element (GGCCACGTGACC) which was recognized by other HLH proteins.[24] Expression of E6 suppressed the function of c-Myc, which showed a link between the two.
In 1996, it was found that Myc heterodimerizes with MAX and that this heterodimeric complex could bind to the CAC(G/A)TG E-box sequence and activate transcription.[25]
In 1998, it was concluded that the function of c-Myc depends upon activating transcription of particular genes through E-box elements.[26]
MYOD1 (MyoD)[edit]
MyoD comes from the Mrf bHLH family and its main role is myogenesis, the formation of muscular tissue.[9] Other members in this family include myogenin, Myf5, Myf6, Mist1, and Nex-1.
When MyoD binds to the E-box motif CANNTG, muscle differentiation and expression of muscle-specific proteins is initiated.[27] The researchers ablated various parts of the recombinant MyoD sequence and concluded that MyoD used encompassing elements to bind the E-box and the tetralplex structure of the promoter sequence of the muscle specific gene α7 integrin and sarcomeric sMtCK.
MyoD regulates HB-EGF (Heparin-binding EGF-like growth factor), a member of the EGF (Epidermal growth factor) family that stimulates cell growth and proliferation.[9] It plays a role in the development of hepatocellular carcinoma, prostate cancer, breast cancer, esophageal cancer, and gastric cancer.
MyoD can also bind to noncanonical E boxes of MyoG and regulate its expression.[28]
MyoG (Myogenin)[edit]
MyoG belongs to the MyoD transcription factor family. MyoG-E-Box binding is necessary for neuromuscular synapse formation as an HDAC-Dach2-myogenin signaling pathway in skeletal muscle gene expression has been identified.[29] Decreased MyoG expression has been shown in patients with muscle wasting symptom.[30]
MyoG and MyoD have also been shown to involve in myoblast differentiation.[31] They act by transactivating cathepsin B promotor activity and inducing its mRNA expression.
TCF3 (E47)[edit]
E47 is produced by alternative spliced E2A in E47 specific bHLH-encoding exons. Its role is to regulate tissue specific gene expression and differentiation. Many kinases have been associated with E47 including 3pk and MK2. These 2 proteins form a complex with E47 and reduce its transcription activity.[32] CKII and PKA are also shown to phosphorylate E47 in vitro.[33][34][35]
Similar to other E-box binding proteins, E47 also binds to the CANNTG sequence in the E-box. In homozygous E2A knock-out mice, B cells development stops before the DJ arrangement stage and the B cells fail to mature.[36] E47 has been shown to bind either as heterodimer(with E12)[37] or as homodimer(but weaker).[38]
Recent research[edit]
Although the structural basis for how BMAL1/CLOCK interact with the E-box is unknown, recent research has shown that the bHLH protein domains of BMAL1/CLOCK are highly similar to other bHLH containing proteins, e.g. Myc/Max, which have been crystallized with E-boxes.[39] It is surmised that specific bases are necessary to support this high affinity binding. Furthermore, the sequence constraints on the region around the circadian E-box are not fully understood: it is believed to be necessary but not sufficient for E-boxes to be randomly spaced from each other in the genetic sequence in order for circadian transcription to occur. Recent research involving the E-box has been aimed at trying to find more binding proteins as well as discovering more mechanisms for inhibiting binding.
Researchers at the Medical School of Nanjing University found that the amplitude of FBXL3 (F-box/Leucine rich-repeat protein) is expressed via an E-box.[40] They studied mice with FBXL3 deficiency and found that it regulates feedback loops in circadian rhythms by affecting circadian period length.
A study published April 4, 2013 by researchers at Harvard Medical School found that the nucleotides on either side of an E-box influences which transcription factors can bind to the E-box itself.[41] These nucleotides determine the 3-D spatial arrangement of the DNA strand and restrict the size of binding transcription factors. The study also found differences in binding patterns between in vivo and in vitro strands.
References[edit]
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^ Chaudhary, J; Skinner, M K. (May 1999). "Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells". Mol Endocrinol. 13 (5): 774–786. doi:10.1210/mend.13.5.0271. PMID 10319327.
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^ Murre, C; Mc Caw, P S; Vaessin, H; et al. (Aug 1989). "Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence". Cell. 58 (3): 537–544. doi:10.1016/0092-8674(89)90434-0. PMID 2503252. S2CID 29339773.
^ Henthorn, P; Kiledjian, M; Kadesch, T (1990). "Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif". Science. 247 (4941): 467–470. Bibcode:1990Sci...247..467H. doi:10.1126/science.2105528. PMID 2105528.
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^ Honma, S; Kawamoto, T; Takagi, Y; Fujimoto, K; Sato, F; Noshiro, M; Kato, Y; Honma, K. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–844. Bibcode:2002Natur.419..841H. doi:10.1038/nature01123. PMID 12397359. S2CID 4426418.
^ Ripperger, J A.; Schibler, U. (Mar 2006). "Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions" (PDF). Nat. Genet. 38 (3): 369–374. doi:10.1038/ng1738. PMID 16474407. S2CID 13433446.
^ Prendergast, G C; Ziff, E B. (Jan 1991). "Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region". Science. 251 (4990): 186–189. Bibcode:1991Sci...251..186P. doi:10.1126/science.1987636. PMID 1987636.
^ Desbarats, L; Gaubatz, S; Eilers, M. (Feb 1996). "Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc". Genes Dev. 10 (4): 447–460. doi:10.1101/gad.10.4.447. PMID 8600028.
^ Xiao, Q; Claassen, G; Shi, J; Adachi, S; Seivy, J; Hann, S R. (Dec 1998). "Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis". Genes Dev. 12 (24): 3803–3808. doi:10.1101/gad.12.24.3803. PMC 317265. PMID 9869633.
^ Shklover, J; Etzioni, S; Weisman-Shomer, P; Yafe, A; Bengal, E; Fry, M. (2007). "MyoD uses overlapping but distinct elements to bind E-box and tetraplex structures of regulatory sequences of muscle-specific genes". Nucleic Acids Res. 35 (21): 7087–7095. doi:10.1093/nar/gkm746. PMC 2175354. PMID 17942416.
^ Bergstrom, D. A.; Penn, B. H.; Strand, A.; Perry, R. L.; Rudnicki, M. A.; Tapscott, S. J. (2002). "Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression". Mol. Cell. 9 (3): 587–600. doi:10.1016/s1097-2765(02)00481-1. PMID 11931766.
^ Tang, H; Goldman, D (2006). "Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade". Proc Natl Acad Sci USA. 103 (45): 16977–16982. Bibcode:2006PNAS..10316977T. doi:10.1073/pnas.0601565103. PMC 1636564. PMID 17075071.
^ Ramamoorthy, S; Donohue, M; Buck, M. (2009). "Decreased Jun-D and myogenin expression in muscle wasting of human cachexia". Am J Physiol Endocrinol Metab. 297 (2): E392–401. doi:10.1152/ajpendo.90529.2008. PMC 2724118. PMID 19470832.
^ Jane, D.T.; Morvay, L.C.; Koblinski, J.; et al. (2002). "Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene expression during human myoblast differentiation". Biol. Chem. 383 (12): 1833–1844. doi:10.1515/BC.2002.207. PMID 12553720. S2CID 26010667.
^ Neufeld, Bernd; Grosse-Wilde, Anne; Hoffmeyer, Angelika; Jordan, Bruce W. M.; Chen, Peifeng; Dinev, Dragomir; Ludwig, Stephan; Rapp, Ulf R. (7 July 2000). "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". Journal of Biological Chemistry. 275 (27): 20239–20242. doi:10.1074/jbc.C901040199. PMID 10781029.
^ Johnson, Sally E.; Wang, Xueyan; Hardy, Serge; Taparowsky, Elizabeth J.; Konieczny, Stephen F. (April 1996). "Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation". Molecular and Cellular Biology. 16 (4): 1604–1613. doi:10.1128/MCB.16.4.1604. PMC 231146. PMID 8657135.
^ Sloan, Steven R.; Shen, Chun-Pyn; McCarrick-Walmsley, Ruth; Kadesch, Tom (December 1996). "Phosphorylation of E47 as a potential determinant of B-cell-specific activity". Molecular and Cellular Biology. 16 (12): 6900–6908. doi:10.1128/MCB.16.12.6900. PMC 231693. PMID 8943345.
^ Shen, Chun-Pyn; Kadesch, Tom (August 1995). "B-cell-specific DNA binding by an E47 homodimer". Molecular and Cellular Biology. 15 (8): 4518–4524. doi:10.1128/MCB.15.8.4518. PMC 230691. PMID 7623842.
^ Bain, Gretchen; Maandag, Els C.; Izon, David J.; Amsen, Derk; Kruisbeek, Ada M.; Weintraub, Bennett C.; Krop, Ian; Schlissel, Mark S.; Feeney, Ann J.; van Roon, Marian; van der Valk, Martin; te Riele, Hein P.J.; Berns, Anton; Murre, Cornelius (2 December 1994). "E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements". Cell. 79 (5): 885–92. doi:10.1016/0092-8674(94)90077-9. PMID 8001125. S2CID 34325904.
^ Lassar, Andrew B.; Davis, Robert L.; Wright, Woodring E.; Kadesch, Tom; Murre, Cornelius; Voronova, Anna; Baltimore, David; Weintraub, Harold (26 July 1991). "Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo". Cell. 66 (2): 305–15. doi:10.1016/0092-8674(91)90620-E. PMID 1649701. S2CID 25957022.
^ Murre, Cornelius; McCaw, Patrick Schonleber; Vaessin, H.; Caudy, M.; Jan, L.Y.; Jan, Y.N.; Cabrera, Carlos V.; Buskin, Jean N.; Hauschka, Stephen D.; Lassar, Andrew B.; Weintraub, Harold; Baltimore, David (11 August 1989). "Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence". Cell. 58 (3): 537–44. doi:10.1016/0092-8674(89)90434-0. PMID 2503252. S2CID 29339773.
^ Muñoz, E; Brewer, M; Baler, R. (Sep 2002). "Circadian Transcription: THINKING OUTSIDE THE E-BOX". J Biol Chem. 277 (39): 36009–36017. doi:10.1074/jbc.m203909200. PMID 12130638.
^ Shi, G; Xing, L; Liu, Z; et al. (2013). "Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock". Proc Natl Acad Sci U S A. 110 (12): 4750–5. Bibcode:2013PNAS..110.4750S. doi:10.1073/pnas.1302560110. PMC 3606995. PMID 23471982.
^ Gordân, R; Shen, N; Dror, I; Zhou, T; Horton, J; Rohs, R; Bulyk, ML. (Apr 2013). "Genomic Regions Flanking E-Box Binding Sites Influence DNA Binding Specificity of bHLH Transcription Factors through DNA Shape". Cell Rep. 3 (4): 1093–104. doi:10.1016/j.celrep.2013.03.014. PMC 3640701. PMID 23562153.
External links[edit]
E-Box+Elements at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
vteTranscription (Bacterial, Eukaryotic)Transcriptional regulationprokaryotic
Operon
lac operon
trp operon
gab operon
Gua Operon
ara operon
gal operon
Repressor
lac repressor
trp repressor
eukaryoticHistone-modifying enzymes(histone/nucleosome):
Histone methylation/Histone methyltransferase
EZH2
Histone demethylase
Histone acetylation and deacetylation
Histone deacetylase HDAC1
Histone acetyltransferase
DNA methylation:
DNA methyltransferase
Chromatin remodeling:
CHD7
both
Transcription coregulator
Activator
Coactivator
Corepressor
Inducer
Promotion
Promoter
Pribnow box
TATA box
BRE
CAAT box
Response element
Enhancer
E-box
Response element
Insulator
Silencer
Internal control region
Initiation
Bacterial
Eukaryotic
Archaeal transcription factor B
Elongation
bacterial RNA polymerase: rpoB
eukaryotic RNA polymerase: RNA polymerase II
Termination(bacterial, eukaryotic)
Terminator
Intrinsic termination
Rho factor
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eBox_Framework: ebox是类似于arduino的一层api，简化stm32编程
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优化其他工程对AC6的支持
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MIT
ebox_stm32
ebox_stm32特点
1.在STM32的库文件的基础上封装一层类似于Arduino的API。
2.使得STM32也可以使用arduino的大部分驱动。驱动程序从github上下载后稍作修改就可以使用。
3.快速实现底层驱动代码，减少STM32开发人员编写、调试器件驱动的工作量，提高驱动的重复利用率。
支持芯片
1、STM32F0系列
2、STM32F1系列
3、STM32F4系列
如何编译
本项目使用MDK 5编译
固件库支持
MCU芯片的全部外设（Gpio，Exti，Timer，Uart，Pwm，Spi，I2c，Adc，Wdg等等）
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Encyclopedia of Cancer pp 947–950Cite as
Home
Encyclopedia of Cancer
Reference work entry
E-Box
Britta Mädge2
Reference work entry
1136 Accesses
1
Citations
7
Altmetric
Synonyms
E-box; E motif
Definition
E-box is the collective term for DNA motifs with the consensus sequence CANNTG. E-boxes appear in a broad variety of promoters and enhancers and serve as protein binding sites. Proteins with affinity to this motif belong to the basic helix-loop-helix (bHLH) class of transcription factors, which can act as activators of transcription as well as repressors. More than 240 bHLH proteins are known to date in eukaryotes ranging from yeast to human, and the number continues to grow. Their binding specificity depends on both the nature of the “NN” nucleotides and sequences in the vicinity of the E-box. Genes containing E-boxes are activated during important developmental processes and some are described to be involved in cancer development and/or progression.
Characteristics
The DNA sequence “CAGGTGGC” was originally identified in 1985 within the sequence of the immunoglobulin enhancers, the first enhancers found to be activated in a tissue-specific manner....
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ReferencesMurre C, McCaw PS, Baltimore D (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777–783PubMed
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Ellenberger T, Fass D, Arnaud M et al. (1994) Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev 8:979–980
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Atchley WR, Fitch WM (1997) A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci USA 94:5172–5176PubMed
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Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eukaryotic organisms. Mol Cell Biol 20:429–440PubMed
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Download referencesAuthor informationAuthors and AffiliationsDKFZ, Heidelberg, GermanyBritta MädgeAuthorsBritta MädgeView author publicationsYou can also search for this author in
PubMed Google ScholarEditor informationEditors and AffiliationsDirector Division of Tumour Genetics (B030), German Cancer Research Center (DKFZ), 69120, Im Neuenheimer Feld 280, Heidelberg, GermanyManfred Schwab (Professor for Genetics) (Professor for Genetics)Rights and permissionsReprints and permissionsCopyright information© 2008 Springer-Verlag Berlin Heidelberg New YorkAbout this entryCite this entryMädge, B. (2008). E-Box.
In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_1795Download citation.RIS.ENW.BIBDOI: https://doi.org/10.1007/978-3-540-47648-1_1795
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life SciencesShare this entryAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard
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E-box是什么？(基因里的..)
x是什么？(基因里的..)登录网页微信知乎图片视频医疗汉语问问更多»我要提问首页问题分类特色搜狗指南问豆商城个人中心263,658,171问题已被解决QQ一键登录搜索生物E-box是什么？(基因里的..)匿名用户431 次浏览2012.09.10 提问我来回答提交答案匿名 最佳答案本回答由达人推荐dear2016.10.27 回答是一种DNA序列，通常位于在一个启动子区域的基因的上游。 It is a transcription factor binding site where the specific sequence of DNA, CANNTG, is recognized by proteins that can bind to it to help initiate transcription of the gene.它是一种转录因子结合位点，可以绑定到它来帮助启动基因的转录的蛋白质的特定序列的DNA，CANNTG，确认。Once transcription factors bind to promoters, they allow for association of other enzymes which will copy the DNA into mRNA .一旦转录因子结合的启动子，它们允许将复制的DNA到mRNA的其他酶的关联。The consensus sequence for the E-box element is CANNTG, with a palindromic canonical sequence of CACGTG. [ 1 ]Transcription factors containing the basic helix-loop-helix protein structural motif typically bind to E-boxes or related variant sequences and enhance transcription of the downstream gene.共识的E-box元素的顺序 CANNTG，典型的回文序列CACGTG [1]含有基本的螺旋-环-螺旋蛋白的结构基序的转录因子通常绑定到E-盒或相关变体序列和增强转录的下游基因。10评论其他回答(1)其他回答(1条回答)Downey2012.09.10 回答华硕的e-box？那绝对没有bug，因为都不能运行战争机器，怎么会有bug呢！ 战争机器系列作为xbox360的独占游戏，其他平台的主机都没有发行。抢首赞评论你的每个回答都是帮助，马上参与关闭关闭修改您的问题E-box是什么？(基因里的..)E-box是什么？(基因里的..)问题补充说明：还可以输入200字添加图片javascript:void((function(){document.open();document.domain='sogou.com';document.close()})());还可添加0张上传说明: 每张图片大小不超过5M，格式为jpg、bmp、png问题分类正确的分类能够获得更专业的回答生物搜索问题悬赏0051020304050您目前问豆为: 0提交置顶你想知道的这里都有已解决问题:263,658,171新手帮助如何提问如何回答权威合作企业合作在线咨询投诉建议举报不良信息未成年举报入口搜狗问问小程序企业推广 – 输入法 – 浏览器 – 隐私政策 – 免责声明 – 用户协议 – 帮助© 2024 SOGOU.COM 京ICP备11001839号GitHub - eboxmaker/eBox_Framework: ebox是类似于arduino的一层api，简化stm32编程
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masterBranchesTagsGo to fileCodeFolders and filesNameNameLast commit messageLast commit dateLatest commit History1,415 Commits0.software_tools0.software_tools ProjectProject componentcomponent docdoc eboxebox exampleexample mcuLibmcuLib osos useruser .gitignore.gitignore CoolFormatList.cflistCoolFormatList.cflist LICENSELICENSE README.mdREADME.md keilkill.batkeilkill.bat sh.exe.stackdumpsh.exe.stackdump View all filesRepository files navigationREADMEMIT licenseebox_stm32
ebox_stm32特点
1.在STM32的库文件的基础上封装一层类似于Arduino的API。
2.使得STM32也可以使用arduino的大部分驱动。驱动程序从github上下载后稍作修改就可以使用。
3.快速实现底层驱动代码，减少STM32开发人员编写、调试器件驱动的工作量，提高驱动的重复利用率。
支持芯片
1、STM32F0系列
2、STM32F1系列
3、STM32F4系列
如何编译
本项目使用MDK 5编译
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数字滤波器（高通，低通，带通）
PID控制器
IO事件管理器（IO事件驱动）
色彩管理器（HSL,HSV,RGB）
万年历
线性回归（主要用于数据采集器的校准）
JSON
FreeModbus
gui
论坛支持
bbs.eboxmaker.com
About
ebox是类似于arduino的一层api，简化stm32编程
Resources
Readme
License
MIT license
Activity
Stars
205
stars
Watchers
32
watching
Forks
100
forks
Report repository
Releases
4
V2.4
Latest
Aug 19, 2021
+ 3 releases
Packages
0
No packages published
Contributors
10
Languages
C
86.4%
C++
9.8%
Assembly
3.3%
Ruby
0.2%
Python
0.1%
Shell
0.1%
Other
0.1%
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